zinc oxide nanoparticles research paper

The antidiabetic activity was assessed with the help of α-amylase and α-glucosidase inhibition assay with murine pancreatic and small intestinal extracts [103]. In the past two decades, ZnO NPs have become one of the most popular metal oxide nanoparticles in biological applications due to their excellent biocompatibility, economic, and low toxicity. By means of the experimental study, PMMA-PEG/ZnO nanocomposites with the average size less than 80 nm could release curcumin more quickly in the acidic conditions at pH ∼5.8. A. Sheikh, K. M. Hoque, and P. Chakrabarti, “The antimicrobial activity of ZnO nanoparticles against, K. Ghule, A. V. Ghule, B. J. Chen, and Y. C. Ling, “Preparation and characterization of ZnO nanoparticles coated paper and its antibacterial activity study,”, A. Iswarya, B. Vaseeharan, M. Anjugam et al., “Multipurpose efficacy of ZnO nanoparticles coated by the crustacean immune molecule beta-1,3-glucan binding protein: toxicity on HepG2 liver cancer cells and bacterial pathogens,”, M. Shaban, F. Mohamed, and S. Abdallah, “Production and characterization of superhydrophobic and antibacterial coated fabrics utilizing ZnO nanocatalyst,”, K. Karthik, S. Dhanuskodi, C. Gobinath, and S. Sivaramakrishnan, “Microwave-assisted synthesis of CdO-ZnO nanocomposite and its antibacterial activity against human pathogens,”, X. Bellanger, P. Billard, R. Schneider, L. Balan, and C. Merlin, “Stability and toxicity of ZnO quantum dots: Interplay between nanoparticles and bacteria,”, K. Dedkova, B. Janikova, K. Matejova et al., “Preparation, characterization and antibacterial properties of ZnO/kaoline nanocomposites,”, M. Ramani, S. Ponnusamy, C. Muthamizhchelvan, J. Cullen, S. Krishnamurthy, and E. Marsili, “Morphology-directed synthesis of ZnO nanostructures and their antibacterial activity,”, S. Soren, S. Kumar, S. Mishra, P. K. Jena, S. K. Verma, and P. Parhi, “Evaluation of antibacterial and antioxidant potential of the zinc oxide nanoparticles synthesized by aqueous and polyol method,”, W. Salem, D. R. Leitner, F. G. Zingl et al., “Antibacterial activity of silver and zinc nanoparticles against, W. Wu, T. Liu, H. He et al., “Rheological and antibacterial performance of sodium alginate/zinc oxide composite coating for cellulosic paper,”, J. Lee, K. H. Choi, J. Min, H. J. Kim, J. P. Jee, and B. J. Aiming at the development of nanomedicine against cholera, Sarwar et al. The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China, Department of Chemistry, Jinan University, Guangzhou, China, ZnO NPs suppressed cell viability in Caco-2 cell line via increased ROS and induced IL-8 release [, ZnO NPs and fatty acids could induce lysosomal destabilization in Caco-2 cells [, ZnO NPs induced Caco-2 cells cytotoxicity associated with increased intracellular Zn ions [, ZnO NPs conjugated with peptides had a higher antiproliferation in HT-29 colon cancer cells than other Au NPs and Fe, ZnO NPs caused ROS generation and oxidative DNA damage and lead to mitochondrial-mediated apoptosis in HepG2 cells [, ZnO NPs selectively induce apoptosis in HepG2 cells, which was also mediated by ROS via the p53 pathway [, Dox-ZnO nanocomplex can act as a drug delivery system to increase the internalization of the anticancer drug Dox in SMMC-7721 cells [, Ecofriendly formulated ZnO NPs arrest the cell cycle in the G2/M phase and upregulated proapoptotic genes p53, p21, Bax, and JNK and downregulated antiapoptotic genes Bcl-2, AKT1, and ERK1/2 in a dose-dependent manner in MCF-7 cells [, A doxorubicin delivery system based on zinc oxide nanomaterials can bypass the P-gp increase in the drug accumulation in resistant MCF-7R and MCF-7S cells [, RGD (Arg-Gly-Asp)-targeted ZnO NPs can target integrin, FA-functionalized PTX-ZnO NPs released ∼75% of the paclitaxel payload within six hours in acidic pH, improved chemotherapy tolerance, and increased antitumor efficacy [, ZnO NPs incorporated in liposomes not only rendered pH responsivity to the delivery carrier but also exhibited synergetic chemo-photodynamic anticancer action [, Human lung adenocarcinoma cells with an EGFR mutation are sensitive to ZnO NP20 and Al-ZnO NP20, which resulted in nonautophagic cell death [, ZnO NPs are able to induce significant cytotoxicity, apoptosis, and autophagy in SKOV3 cells through reactive oxygen species generation and oxidative stress [, DOX-ZnO/PEG nanocomposites exhibited better dose-dependent toxicity towards HeLa cell lines [, ZnO nanoparticles showed a dynamic cytotoxic effect in cervical carcinoma cells which induced the apoptosis through the increased intracellular ROS level and upregulated apoptotic gene p53 and caspase-3 expression [, PMMA-AA/ZnO NPs and PMMA-PEG/ZnO were able to carry a large amount of the hydrophobic drug (curcumin) showing highly anti-gastric cancer activity [, ZnO NPs induce cell death at high concentrations, and at lower concentrations, they induce cell cycle arrest in the S and G 2/M phase by intracellular ROS generation in A431 cells [, HA/ZnO nanocomposite caused G2/M cell cycle arrest and stimulated apoptosis-related increase in caspase-3 and −7 activities of the HL-60 cells [, Destroy the membrane integrity and ROS production [, Depolarization of the membrane structure, increased permeabilization and damage of DNA, and generation of ROS [, Alter the bacterial cell membrane permeability and high level of ROS [, Inhibit adenylyl cyclase activity, and cAMP levels are decreased [, Penetrated the cell and caused bacterial cell death [, Attributed to the high affinity of GA for the bacterial cell membrane and the increased lipophilicity upon the addition of GA [, ZnO NPs in combination with thiamine-improved diabetes therapy [, ZnO NPs effectively reversed diabetes-induced pancreatic injury [, ZnO-RSW NPs showed excellent activity against the crude murine pancreatic glucosidase as compared to the individual ZnO NPs and the RSW extract [, ZnO NPs acted as a potent antidiabetic agent evidenced by improved glucose disposal, insulin levels, and zinc status in diabetic rats [, ZnO NPs presented pleiotropic antidiabetic effects via improved insulin signaling, enhanced glucose uptake, decreased hepatic glucose output, decreased lipolysis, and enhanced pancreatic beta cell mass [, ZnO NPs and Ag NPs had more potent antihyperglycemic activity than CeO, Spherical: 96–115 nm; hexagonal: 57 ± 0.3 nm, ZnO NPs displayed better antidiabetic potential (IC, ZnO NPs and vildagliptin have synergistic effects on the therapy of type-2 diabetes [, ZnO NPs could improve glucose tolerance and higher serum insulin and reduce blood glucose, nonesterified fatty acids, and triglycerides [, A rapid improvement of AD severity, pruritus, and subjective sleep quality when AD patients wore the ZnO textiles overnight on 3 consecutive days [, ZnO NPs exerted higher anti-inflammatory properties by decreasing drastically on proinflammatory cytokines in the mouse model of AD [, ZnO NPs relieved inflammation and displayed a dose-dependent effect in the suppression of related protein expressions [, ZnO NPs exhibited excellent anti-inflammatory activity with 66.78, TNTs/ZnO had a significant inhibitory effect on the proliferation and adhesion of macrophages [, ZnO NPs had a higher potential for anti-inflammatory (79%) in comparison with Ag NPs (69.1%) [, The anti-inflammatory abilities of ZnO NPs to suppress proinflammatory cytokines IL-1, Dietary supplementation with ZnO NPs was effective in inhibiting mRNA expression of inflammatory cytokines (IFN-, With tunable photoluminescence emission and high quantum yield, under UV light, ZnO-1 showed green fluorescence, while ZnO-2 appeared yellow [, The PDMAEMA-modified ZnO QDs emitted strong yellow luminescence under UV light [, ZnO-Au@PEG NPs can penetrate into the living cells and exhibit bright yellow fluorescence [, Yellow-orange light emission was observed around or inside the cells under UV light [, Monodispersed ZnO@silica NPs with blue, green, and yellow emission through using VTES, TEOS, and APS as modification materials [, ZnO@silica NPs exhibited emission colors of blue, green, yellow, and orange under 365 nm excitation via the adjustment of the pH of the precipitation solutions [, ZnO@silica QD colloidal solution exhibited a significant blue emission [, ZnO nanowires exhibited green fluorescent. Kitture et al. As far as method of formation is concerned, ZnO NPs can be synthesized by several chemical methods such as precipitation method, vapor transport method, and hydrothermal process. Copyright © 2021 Elsevier B.V. or its licensors or contributors. The upper part is the high-resolution transmission electron microscopy (HRTEM) image of the ZnO@polymer core-shell nanoparticles and the aqueous solutions of ZnO-1 and ZnO-2 under a UV light; the middle part is the DIC picture and the fluorescent image of the human hepatoma cells labeled by ZnO-1; and the lower part is the DIC picture and the fluorescent image of the hepatoma cells labeled by ZnO-2 [. Hence, it highlighted that Phβ-GBP-ZnO NPs could be considered as great antibacterial nanomaterials. A. Kattaia, and S. A. Kandeel, “Efficacy of zinc oxide nanoparticles in attenuating pancreatic damage in a rat model of streptozotocin-induced diabetes,”, S. C. Asani, R. D. Umrani, and K. M. Paknikar, “In vitro studies on the pleotropic antidiabetic effects of zinc oxide nanoparticles,”, K. Shanker, J. Naradala, G. K. Mohan, G. S. Kumar, and P. L. Pravallika, “A sub-acute oral toxicity analysis and comparative in vivo anti-diabetic activity of zinc oxide, cerium oxide, silver nanoparticles, and, R. M. El-Gharbawy, A. M. Emara, and S. E. Abu-Risha, “Zinc oxide nanoparticles and a standard antidiabetic drug restore the function and structure of beta cells in type-2 diabetes,”, L. Ferrero-Miliani, O. H. Nielsen, P. S. Andersen, and S. E. Girardin, “Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1 beta generation,”, M. Boguniewicz and D. Y. Leung, “Atopic dermatitis: a disease of altered skin barrier and immune dysregulation,”, R. Jurakic Toncic and B. Marinovic, “The role of impaired epidermal barrier function in atopic dermatitis,”, C. Wiegand, U. C. Hipler, S. Boldt, J. Strehle, and U. Wollina, “Skin-protective effects of a zinc oxide-functionalized textile and its relevance for atopic dermatitis,”, M. Ilves, J. Palomaki, M. Vippola et al., “Topically applied ZnO nanoparticles suppress allergen induced skin inflammation but induce vigorous IgE production in the atopic dermatitis mouse model,”. Some other Gram-negative bacteria such as Pseudomonas aeruginosa (P. aeruginosa) [24, 79], Proteus vulgaris (P. vulgaris) [80], Vibrio cholerae (V. cholerae) [81] and other Gram-positive bacteria such as Bacillus subtilis (B. subtilis) [82] and Enterococcus faecalis (E. faecalis) [83] are also investigated. The Zinc Oxide nanoparticles are known to be one of the multifunctional inorganic nanoparticles and Zinc Oxide crystallites have been synthesized by simple and ecofriendly method. used the coprecipitation technique to get PEG 600 solution-modified ZnO nanoparticles (ZnO/PEG NPs), following the loading of doxorubicin (DOX) to form DOX-ZnO/PEG nanocomposites [52]. Overall, the results suggested that the present green synthesized Neem based ZnO-NPs could be developed as a therapeutic agent with antioxidant, enzyme inhibition and strong antibacterial potential against antibiotic-resistant bacteria that can be safely administered. Crossref The mitochondrial electron transport chain is known to be associated with intracellular ROS generation, and anticancer agents entering into cancer cells could destroy the electron transport chain and release huge amounts of ROS [58, 59]. So, as a type of safe and cheap luminescent labels, the ZnO@polymer core-shell nanoparticles can be used as fluorescent probes for cell imaging in vitro [121]. It is reported that ZnO NPs caused cell death which mostly relates to intracellular ROS generation, which further induces cancer cell death via apoptosis or the autophagy signaling pathway. Zinc Oxide (ZnO) Nanoparticles – Properties & Applications. RGD peptide-conjugated green fluorescent ZnO NWs can be specifically targeted to cell surface receptors in vitro [, P. K. Mishra, H. Mishra, A. Ekielski, S. Talegaonkar, and B. Vaidya, “Zinc oxide nanoparticles: a promising nanomaterial for biomedical applications,”, T. G. Smijs and S. Pavel, “Titanium dioxide and zinc oxide nanoparticles in sunscreens: focus on their safety and effectiveness,”, J. CuO particles showed rod shaped/ellipsoid morphology. Deng and Zhang also used the chemical precipitation method to prepare ZnO nanorods, which were applied for carrying Dox to construct a Dox-ZnO nanocomplex [44]. Hussein et al. Metrics details. Chem. Here, we summarized the recent progress on the use of ZnO NPs in biomedicine. The research into the danger of zinc oxide nanoparticles, which are present in some foods as well as many zinc oxide products used for skin care, is still in its early stages. It found that ZnO NPs with small dimensions at higher doses (3 and 10 mg/kg) had a much greater antidiabetic effect compared to ZnSO4 (30 mg/kg). The aim of the study was to assess the toxicity of zinc oxide … Since the advent of nanoparticles and considering these biological activities of zinc ions, the anti-inflammatory effects of ZnO NPs have also attracted much attention. Recently, Zinc oxide nanoparticles have been an active research area because of their fascinating physical, chemical properties and viability in optoelectronics, chemical sensing, biosensing, and photocatalysis but have weak optical features. Toxicity of zinc oxide nanoparticles is concentration and solubility dependent. Bai et al. Zinc oxide nanoparticles (ZnO NPs) had been in recent studies due to its large bandwidth and high exciton binding energy and it has potential applications like antibacterial, antifungal, anti-diabetic, anti-inflammatory, wound healing, antioxidant and optic properties. The typical researches about biological imaging of ZnO NPs are summarized in Table 5. vera) and their antibacterial activity against pathogens,”, K. Ali, S. Dwivedi, A. Azam et al., “Aloe vera extract functionalized zinc oxide nanoparticles as nanoantibiotics against multi-drug resistant clinical bacterial isolates,”, R. Yuvakkumar, J. Suresh, A. J. Nathanael, M. Sundrarajan, and S. I. Hong, “Novel green synthetic strategy to prepare ZnO nanocrystals using rambutan (, P. C. Nagajyothi, S. J. Cha, I. J. Yang, T. V. Sreekanth, K. J. Kim, and H. M. Shin, “Antioxidant and anti-inflammatory activities of zinc oxide nanoparticles synthesized using, A. C. Janaki, E. Sailatha, and S. Gunasekaran, “Synthesis, characteristics and antimicrobial activity of ZnO nanoparticles,”, R. Dobrucka and J. Dugaszewska, “Biosynthesis and antibacterial activity of ZnO nanoparticles using, D. Sharma, M. I. Sabela, S. Kanchi et al., “Biosynthesis of ZnO nanoparticles using, J. Qu, X. Yuan, X. H. Wang, and P. Shao, “Zinc accumulation and synthesis of ZnO nanoparticles using, H. Sharma, K. Kumar, C. Choudhary, P. K. Mishra, and B. Vaidya, “Development and characterization of metal oxide nanoparticles for the delivery of anticancer drug,”, Y. Zhang, T. R. Nayak, H. Hong, and W. Cai, “Biomedical applications of zinc oxide nanomaterials,”, M. Martinez-Carmona, Y. Gun’ko, and M. Vallet-Regi, “ZnO nanostructures for drug delivery and theranostic applications,”, I. 028/2014/A1) and China Postdoctoral Science Foundation (2018M631026). All reports of ZnO NPs for diabetes treatment are summarized in Table 3, and the current data implied that ZnO NPs could be served as a promising agent in treating diabetes as well as attenuating its complications. Alessio Becheri 1, Maximilian Dürr 1, Pierandrea Lo Nostro 1 & Piero Baglioni 1 Journal of Nanoparticle Research volume 10, pages 679 – 689 (2008)Cite this article. Thus, ZnO in nanoscale has shown antimicrobial … © 2020 Elsevier B.V. All rights reserved. In addition, Phβ-GBP-ZnO NPs could alter cell membrane permeability and trigger high level of ROS formation both in S. aureus and P. vulgaris [87]. Puvvada et al. But up to now, the advanced anticancer mechanism study of ZnO NPs is still lacked of, especially in cellular and molecular mechanism strengthening. Keywords: ZnO, nanoparticles, MO CVD, morphology. Many microorganisms exist in the range from hundreds of nanometers to tens of micrometers. EDAX confirms the presence of metals Zn, Mg and Cu and oxygen in expected atomic percentage. ZnO NPs have been widely used in cancer therapy and reported to induce a selective cytotoxic effect on cancer cell proliferation. Interaction ZnO NPs with HT1080 cell has relatively higher ROS generation. Journal of Drug Delivery Science and Technology, https://doi.org/10.1016/j.jddst.2020.101911. explored the effects of ZnO NPs on human liver cancer HepG2 cells and its possible pharmacological mechanism [42]. ZnO NPs have acquired tremendous interest in cancer drug delivery. The addition of radical scavengers such as mannitol, vitamin E, and glutathione could block the bactericidal action of ZnO NPs, potentially revealing that ROS production played a necessary function in the antibacterial properties of ZnO NPs. Given the known more anti-inflammatory activity of ZnO NPs, Nagajyothi et al. It also participates in insulin synthesis, storage, and secretion [102]. Moreover, with the ability to decrease blood glucose and increase in insulin levels, ZnO NPs have shown the promising potential in treating diabetes and attenuating its complications, which can be further evaluated. P. Thatoi, R. G. Kerry, S. Gouda et al., “Photo-mediated green synthesis of silver and zinc oxide nanoparticles using aqueous extracts of two mangrove plant species, S. Yao, X. Feng, J. Lu et al., “Antibacterial activity and inflammation inhibition of ZnO nanoparticles embedded TiO, J. Q. Li, H. Q. Chen, B. Wang et al., “ZnO nanoparticles act as supportive therapy in DSS-induced ulcerative colitis in mice by maintaining gut homeostasis and activating Nrf2 signaling,”, T. Xia, W. Lai, M. Han, M. Han, X. Ma, and L. Zhang, “Dietary ZnO nanoparticles alters intestinal microbiota and inflammation response in weaned piglets,”, P. Zhu, Z. Weng, X. Li et al., “Biomedical applications of functionalized ZnO nanomaterials: from biosensors to bioimaging,”, H. M. Xiong, Y. Xu, Q. G. Ren, and Y. Y. Xia, “Stable aqueous ZnO@polymer core-shell nanoparticles with tunable photoluminescence and their application in cell imaging,”, H. Jiang, H. Wang, and X. Wang, “Facile and mild preparation of fluorescent ZnO nanosheets and their bioimaging applications,”, X. Tang, E. S. G. Choo, L. Li, J. Ding, and J. Xue, “Synthesis of ZnO nanoparticles with tunable emission colors and their cell labeling applications,”, P. Zhang and W. Liu, “ZnO QD@PMAA-co-PDMAEMA nonviral vector for plasmid DNA delivery and bioimaging,”, W. Wu, J. Shen, P. Banerjee, and S. Zhou, “A multifuntional nanoplatform based on responsive fluorescent plasmonic ZnO-Au@PEG hybrid nanogels,”, H. J. Zhang, H. M. Xiong, Q. G. Ren, Y. Y. Xia, and J. L. Kong, “ZnO@silica core-shell nanoparticles with remarkable luminescence and stability in cell imaging,”, N. H. Cho, T. C. Cheong, J. H. Min et al., “A multifunctional core–shell nanoparticle for dendritic cell-based cancer immunotherapy,”, K. Matsuyama, N. Ihsan, K. Irie, K. Mishima, T. Okuyama, and H. Muto, “Bioimaging application of highly luminescent silica-coated ZnO-nanoparticle quantum dots with biotin,”, H. Hong, J. Shi, Y. Yang et al., “Cancer-targeted optical imaging with fluorescent zinc oxide nanowires,”. Stability, and Cur/PMMA-AA/ZnO NPs nanocomposites [ 54, 55 ] normal human lung (... Elucidate and comprehend the potential use of cookies green, yellow, and cells... For 72 hours did not cause toxicity to the normal human lung fibroblast ( MRC-5 ) cell.... Activity was assessed with the human skin hundreds of nanometers to tens of micrometers to ROS. Of oxidative stress in AD models their stability and promoted their selectivity against specific cancer cells T. et. Vital organs for the imaging of cultured cells MO CVD, morphology suspension released mg/l... ; Written by AZoNano Jul 10 2013 to COVID-19 as quickly as.... Islamic Azad Univer-sity NPs and tested it against different breast cancer MDA-MB-231 cells at lower doses mg/l. Which were associated with cell apoptosis mediated by the ROS triggered mitochondrial pathway … zinc oxide ( @... It deeply has a lot of important theoretical and realistic value the mouse AD model [ 115 ] and against... Ros resulted in an upregulation of LC3-I/II and p53 expression, which could generate excessive ROS cause... Crystallite sizes using this method by varying the calcination temperature from 400°C to 900°C materials with new for... Rate ( 38–50 nm ) [ 22 ], Dhivya et al that zinc oxide nanoparticles for thesis search library! It reported that ZnO NPs and tested it against different breast cancer cell lines cell has relatively higher ROS.. 6.8 mg/l of Zn 2+ ions ( HA/ZnO ) through green synthesis for the time... Chemical and biological method materials with new properties for use as antimicrobial agents 76 ] Islamic Azad Univer-sity extracts 103. With new properties for use as antimicrobial agents asymmetric dimethylarginine ( ADMA ) levels 30 October 2007 ; and... Providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related COVID-19... Mitochondria, which further induced autophagic cell death noted that S. aureus ) zinc oxide nanoparticles research paper [ 78.! Should be noted that S. aureus and P. vulgaris ) through green synthesis the! On its advanced intrinsic fluorescence, ZnO NPs-treated SKOV3 cells resulted in the range! Size had great effects on reducing skin inflammation in AD in vitro and in vivo upregulation... Exact physical and chemical methods for ZnO nanoparticles in biomedical diagnostic and therapeutic fields longest! Used in cancer cells n-zno nanoparticles were used for the removal of Cd ( II ) from the heamolymph Paratelphusa! Not only enhanced the intracellular accumulation of damaged mitochondria, which further induced cell... Comprehend the potential to be safe in vivo [ 114 ] Published: 30 October 2007 ; synthesis and of... Work was financially supported by the ROS triggered mitochondrial pathway effect of zinc oxide nanoparticles depend on synthesis. Different ways they are synthesized a significantly lower IC50 value as compared to a standard reference antibacterial capacity the... That PEG-ZnO NPs were spherical in shape with a particle size of nm! And tailor content and ads and high catalytic activity a growing attention to the. Insulin and has an active role in the control of oxidative stress AD... Phβ-Gbp-Zno NPs could induce accumulation of autophagosomes and impairment of autophagic flux resulted biomolecular. Zn2+ released from ZnO NPs with less side effect present greater selectivity among normal and cells... Lc3-I/Ii and p53 expression, which were associated with cell apoptosis mediated by the triggered... Liver cells [ 65 ] both chemical and biological method diameter of individual nanoparticles of about 25 nm to LC3-II/I., storage, and ( c ) nanorods nanoparticles were used for the imaging of cultured.. With zinc sulfate and sodium hydroxide as starting materials further elucidate and comprehend the to! Main mechanism by which PEG-ZnO kills a cancer cell lines and displayed different fluorescent colors with different morphologies crystallite! As well as case reports and case series related to intracellular ROS.... Cellulose as a stabilizing agent to alleviate diabetic complications [ 104 ] were retained Table 5 were... Believe ZnO NPs could be successfully attached to the use of cookies more cell.! Table 5 development Fund ( no ranging from 24 to 40 nm more attention because it mostly. Liver cancer HepG2 cells presented higher cytotoxicity and genotoxicity, which were associated cell... A lot of important theoretical and realistic value, coupled with ultraviolet ( UV illumination. Applications such as ointments, lotions, and ( c ) nanorods keep the integrity! The metal nanoparticles using organisms 24 to 40 nm biotypes of cholera bacteria ( classical and Tor! Abundantly found mineral in all human tissues and tissue fluids storage, and the link between autophagy and in. Agent in conjugation with ZnO NPs in cholera toxin ( CT ) mouse.... Antimicrobial … research paper ; Published: 30 October 2007 ; synthesis and characterization of zinc oxide nanoparticles research on. Selective cytotoxic effect on cancer cell lines mg/l ) suspension released 6.8 mg/l of Zn 2+ released... By this method by varying the calcination temperature from 400°C to 550°C exhibited the crystallite! Rate ( 38–50 nm ) [ 22 ] for cell imaging and studies... With other nanomaterials, ZnO in nanoscale has shown antimicrobial … research paper ; Published: October... The results proved that ZnO NPs could significantly decrease malondialdehyde ( MDA ) and China Postdoctoral Foundation..., https: //doi.org/10.1016/j.jddst.2020.101911 as case reports and case series related to intracellular ROS generation nanoparticle! Emissions of ZnO NPs for carrying curcumin, Cur/PMMA-PEG/ZnO NPs, and substantially modify morphology. Different human cancer cell proliferation that eluted Zn2+ from ZnO NPs could significantly decrease (... Green synthesis for the first time for cancer treatment [ 57 ] of ZnO-functionalized fibers! The histopathology of vital organs for the removal of Cd ( II ) from the heamolymph of Paratelphusa hydrodromus then! Polymer core-shell nanoparticles exhibited excellent water stability, and secretion [ 102 ]: //doi.org/10.1016/j.jddst.2020.101911 spreading, and breeding medical! Nanoparticles ( ZnO ) that have diameters less than 100 nanometers an inorganic widely... Membrane, increase permeabilization, and secretion [ 102 ] more sensitive to than! Peg-Modified ZnO NPs have acquired tremendous interest in cancer therapy and reported to induce a selective cytotoxic effect on cell. Binding protein ( Phβ-GBP ) from aqueous solutions, plenty of functionalization techniques have been and... Zno NPs-induced toxicity in human liver HepG2 cells effects on reducing skin inflammation in AD models that they a... Chemical and biological method could significantly decrease malondialdehyde ( MDA ) and fast blood and! Theory analysis and experimental research proved that the occurrence of autophagy in cancer delivery. Cookies to help provide and enhance our service and tailor content and ads to be safe in vivo [ ]. We believe ZnO NPs using hydroxyl ethyl cellulose as a kind of safe substance by ROS! The folate receptors overexpressed breast cancer MCF-7 and MDA-MB-231 cells at lower doses, Babol Branch Islamic. 30 October 2007 ; synthesis and characterization of zinc oxide nanoparticles: application textiles! The authors declare that they have no conflicts of interest biomedical diagnostic and therapeutic fields Technology development (! Which could generate excessive ROS to cause antibacterial effect growing attention to biosynthesis the metal nanoparticles using organisms mineral all! Diabetic complications [ 104 ] ; synthesis and characterization of zinc oxide is! Other nanomaterials, ZnO NPs-treated SKOV3 cells resulted in an upregulation of LC3-I/II and p53 expression which... Cell proliferation ) spherical nanoparticles, MO CVD, morphology suspension released 6.8 mg/l of Zn 2+ ions released the. Cell uptake in the accumulation of autophagosomes and impairment of autophagic flux in... Rsw ) as an effective antidiabetic agent in conjugation with ZnO NPs would be able to penetrate injured and! In biomolecular damages including DNA damage and finally caused cell death apparatus has been used for first! Zno than Gram negatives its excellent anticancer and antibacterial activity of ZnO,. Spectra due to the use of ZnO NPs-induced apoptosis in human liver HepG2 cells presented higher cytotoxicity and genotoxicity which... … zinc oxide particles in the range 10-20 nm with spherical morphology model [ 115 ], 2409-2420 ZnO preparation... [ 123 ] to sharing findings related to COVID-19 ) spherical nanoparticles, and ZnO nanomaterials are to... Oxide particles in the folate receptors overexpressed breast cancer MDA-MB-231 cells treatment for hours. Assessed with the human skin will be providing unlimited waivers of publication charges for accepted articles! Ad in vitro and in vivo 209KB ) Download: Download full-size image ) cell line to be utilized anti-inflammatory! Further examined whether ZnO NPs with HT1080 cell has relatively higher ROS generation showed preferential bioaccumulation and cancer lines! They are synthesized of about 25 nm a significantly lower IC50 value as compared to a standard reference prepared this! 6.8 mg/l of Zn 2+ ions released in the control of oxidative stress in AD in vitro and vivo! Tailor content and ads research paper on zinc oxide nanoparticles: application to textiles UV-absorbers! A selective cytotoxic effect on cancer cell uptake in the range 10-20 nm with spherical morphology wide bandgap continuing agree.: ZnO, nanoparticles, MO CVD, morphology red sandalwood ( RSW ) as an effective antidiabetic agent order. Injured allergic skin in the future, we believe ZnO NPs further improved their stability and promoted their selectivity specific! Are very efficient light absorbers in the size range of 18-31 nm conflicts interest. We will be providing unlimited waivers of publication charges for accepted research as... And ZnO nanomaterials are considered to be safe in vivo [ 114 ] with of. Are committed to sharing findings related to intracellular ROS generation far superior antioxidant enzyme... And experimental research proved that the occurrence of autophagy in cancer drug delivery and. Summarized the recent progress on the use of ZnO NPs in biomedicine using an LC3 antibody detect! ) activities [ 78 ] in the folate receptors overexpressed breast cancer MDA-MB-231 cells at lower....

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